Table.

Clinical characteristics and laboratory findings in patients with anti-Ma associated encephalitis

Patient no.	Sex	Age, y	Neurologic symptoms	Tumor type	Radiology	Hcrt-1, pg/mL*
1	M	45	EDS (altered sleep habits), depression, memory loss, seizures, abnormal weight gain	Non-seminomatous germ cell tumor of the testis	MRI: T2-weighted lesions in both mesiotemporal regions, ventricular enlargement, temporal lobe atrophy	<100
2	M	22	Severe EDS, lethargy, depression, partial complex seizures	Mixed germ-cell tumor of the testis	MRI: left temporal enhancing abnormalities	<100
3†	F	82	Short-term memory problems, diplopia, opsoclonus, gait difficulty, personality change	Poorly differentiated lung cancer	MRI: Abnormalities in brainstem, periventricular region, and basal ganglia	237
4	F	67	EDS (altered sleep habits), diplopia, downgaze paresis, short-term memory problems, balance difficulties	Adenocarcinoma of the Lung	MRI: nodular enhancing abnormalities in the thalamus and superior collicular region; T2-weighted medial temporal lesions	<100
5	M	38	Severe EDS, lethargy, abulia, hypothalamic dysfunction(hypothyroidism, diabetes insipidus, episodes of hypertermia)	Germ-cell tumor of the testis (seminoma)	MRI: lesions hippocampus, midbrain	<100
6	F	53	Parkinsonism, dementia, vertical gaze limitation, gait difficulty	Adenocarcinoma of the Ovary	MRI: normal	218

^*Hcrt-1 <100: concentration below detection limit of assay.

^†In addition to Ma2, this patient also had Ma1 antibodies.

EDS = excessive daytime sleepiness.