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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Mol Pharmacol. 2008 Jul 29;74(5):1345–1358. doi: 10.1124/mol.108.049551

Figure 1. Chemical modifications of the PHCCC scaffold depicted here do not result in improved potency or efficacy for potentiation of mGluR4 activity.

Figure 1

Structures of synthesized compounds are shown in Supplemental Figure 1. Chemical synthesis is described in Supplemental Methods. Compounds 1a-e and 1k-p were synthesized according to the method of Annoura et al. (Annoura et al., 1998). Compounds 1f-j, 1l, and 1q were synthesized from 1g by the same methods. Compound 1g was prepared from 2-hydroxyacetophenone as described in Silva et al (Silva et al., 1998). A 30 μM final concentration of each compound was added to human mGluR4/Gqi5 cells; 2 ½ minutes later a submaximal (EC20) concentration of glutamate was added and changes in calcium-mediated fluorescence were measured. Results represent mean ± S.E.M. of three independent experiments performed in triplicate.