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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Mol Pharmacol. 2008 Jul 29;74(5):1345–1358. doi: 10.1124/mol.108.049551

Figure 5. VU0003423 selectively potentiated the response of mGluR4 to glutamate when compared with other mGluRs.

Figure 5

A 30 μM final concentration of VU0003423, followed by an EC20 or EC80 concentration of agonist, was applied to the following cell lines to test for selectivity among the mGluRs: rat mGluR1/BHK, human mGluR2/CHO, human mGluR4/Gqi5, rat mGluR5/HEK, rat mGluR7/GIRK, and rat mGluR8/GIRK. Assays for each receptor were carried out as described in Materials and Methods. For mGluR1, 2, 4, 5, and 8, the agonist used was glutamate, whereas the agonist for mGluR7 was L-AP4. Data were normalized to the corresponding response observed in the absence of VU0003423. Results represent the mean ± S.E.M. of 3−4 independent experiments performed in triplicate or quadruplicate.