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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: Prostate. 2008 Sep 15;68(13):1467–1476. doi: 10.1002/pros.20812

Figure 1.

Figure 1

ISH analysis of E-cadherin and MMP-2 and -9 mRNA expression in a RP specimen. Hematoxylin and eosin histology reveals a Gleason 8 adenocarcinoma (stage = pT3b, N0). Hybridization with hyperbiotinylated poly d(T)20 probe confirmed mRNA integrity (not shown). The numbers for E-cadherin, MMP-9, and MMP-2 indicate expression intensities compared with the epithelium of normal glands, which was assigned the value of 100. The M/E ratios [(MMP-2+MMP-9/ 2) ÷ E-cadherin] for the RP specimen were 4.91 (tumor edge) and 1.46 (tumor center) from reviewer 1.