Table I.

M/E ratio assessed by mRNA ISH and grouped by Gleason score and Reviewer.

			MMP/E-cad Ratio
Reviewer	GS	N	Peripheral	P-value	Central	P-value
1	6	7	2.09 (1.09) (0.96, 3.73)		2.63 (1.27) (0.95, 4.76)
	7	16	3.62 (2.20) (0.86, 9.83)		2.30 (0.92) (0.94, 3.99)
	8	8	7.04 (4.69) (0.77, 15.98)		2.44 (1.08) (0.59, 3.98)
	9	5	6.39 (2.54) (3.25, 9.04)	0.02	3.78 (3.34) (1.11, 9.36)	0.88
2	6	7	1.56 (0.49) (0.75, 2.20)		1.21 (0.47) (0.49, 1.84)
	7	16	2.24 (1.33) (0.74, 5.32)		1.37 (0.46) (0.61, 2.38)
	8	8	5.16 (3.47) (2.38, 13.22)		2.64 (1.57) (1.22, 6.14)
	9	5	3.46 (0.61) (2.61, 4.25)	0.0008	1.42 (0.58) (0.91, 2.35)	0.02

Results represent the mean (SD) of the maximum values for each tumor and the range. M/E, matrix metalloproteinase to E-cadherin; ISH, in situ hybridization; GS, Gleason score; N, number.