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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Bioorg Chem. 2008 May 27;36(4):190–197. doi: 10.1016/j.bioorg.2008.04.001

Table 2.

Potencies of Selected Arylstibonic Acids and Camptothecina

compound structure C0.5
(μM)
hTopob vTopo
camptothecin graphic file with name nihms58038t38.jpg 1.2 ± 0.5
(n = 1)		 ~100c
P6954 graphic file with name nihms58038t39.jpg 6.6 ± 0.4
(n = 3.6 ± 0.7)		 1.4 ± 0.6
(n = 1)
P6964 graphic file with name nihms58038t40.jpg 6.5 ± 0.7
(n = 3.9 ± 1.5)		 ≥ 6
P6982 graphic file with name nihms58038t41.jpg 3.4 ± 0.3
(n = 2.0 ± 0.4)		 ≥ 5
13759 graphic file with name nihms58038t42.jpg ~ 6 d 0.21 ± 0.07
(n = 1)
a

Reactions were carried out in the presence of 14 nM pUC19 plasmid DNA substrate and 1 nM hTopo or vTopo.

b

Values in parentheses are Hill coefficients.

c

ref #

d

This compound shows activation and inhibition. The value is the apparent concentration for 50% inhibition.