Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Target-mediated disposition model for denosumab pharmacokinetics. Drug administered subcutaneously gets absorbed (ka) into the plasma compartment (Cp, Vc). Drug can be eliminated (kel) or rapidly bind to the pharmacological target to form a drug-ligand complex (RC). The model also includes the internalization of the drug-ligand complex (kint).
