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Noncompartmental analysis of denosumab pharmacokinetics in multiple myeloma patients
| Dose (mg/kg) | λz (day−1) | AUC (×105ng·day/mL) | CL/F (mL/day/kg) | VSS/F (mL/kg) | MRT (day) |
|---|---|---|---|---|---|
| 0.1 | 0.116 | 0.203 | 4.94 | 119 | 24.2 |
| 0.3 | 0.044 | 1.01 | 2.98 | 104 | 34.9 |
| 1.0 | 0.019 | 5.36 | 1.87 | 116 | 62.3 |
| 3.0 | 0.022 | 9.33 | 3.21 | 158 | 49.2 |
