Table 3.
Fracture Incidence Among the Nonadherent (MPR > 50% ) per 1000 Person-Years and Number Needed to Adhere (NNA) for 1 yr to Prevent One Fracture by Age, Sex, and Fracture Type
| Fracture type† | Events used to compute rate (n) |
Age
|
||||||
|
Women
|
Men*
|
|||||||
| 45–54 | 55–64 | 65–71 | 72–78 | >78 | 45–64 | 65–78 | ||
| Hip | ||||||||
| All pts | 219 | 0.8 | 1.1 | 3.9 | 15.3 | 32.4 | ||
| NNA, All pts | 6058 | 4406 | 691 | 176 | n/a | |||
| Persons w/OP† | 136 | 1.1 | 1.6 | 3.6 | 19.1 | 39.5 | ||
| NNA, persons w/OP† | 5238 | 3601 | 567 | 107 | n/a | |||
| Wrist | ||||||||
| All pts | 354 | 5.5 | 6.6 | 7.2 | 10.7 | 15.5 | ||
| NNA, All pts | 1008 | 840 | n/a | n/a | 117 | |||
| Persons w/OP† | 182 | 6.2 | 7.6 | 9.3 | 12.3 | 18.8 | ||
| NNA, persons w/OP† | 863 | 704 | n/a | n/a | 87 | |||
| Clinical vertebral | ||||||||
| All pts | 193 | 1.5 | 1.9 | 4.0 | 11.4 | 14.2 | ||
| NNA, All pts | 2687 | 2121 | 629 | 221 | 203 | |||
| Persons w/OP† | 134 | 2.5 | 3.5 | 4.6 | 13.3 | 18.2 | ||
| NNA, persons w/OP† | 906 | 647 | 449 | 155 | 136 | |||
| Nonhip, nonvertebral | ||||||||
| All pts | 657 | 8.9 | 10.8 | 11.3 | 25.3 | 36.9 | ||
| NNA, All pts | 773 | 637 | 580 | 259 | 98 | |||
| Persons w/OP† | 332 | 10.7 | 13.1 | 14.6 | 26.7 | 45.1 | ||
| NNA, persons w/OP† | 561 | 458 | 525 | 287 | 81 | |||
| Any nonvertebral | ||||||||
| All pts | 796 | 9.3 | 11.4 | 14.7 | 35.2 | 61.0 | 8.4 | 13.1 |
| NNA, All pts | 780 | 636 | 340 | 142 | 290 | 863 | 553 | |
| Persons w/OP† | 410 | 11.4 | 14.0 | 17.5 | 38.8 | 74.9 | 9.5 | 26.7 |
| NNA, persons w/OP† | 549 | 447 | 248 | 112 | 180 | 659 | 162 | |
* Rates not provided when the number of events for that cell was <10.
† As coded from a physician evaluation and management (E/M) claim.
NNA, number needed to adhere, defined as the number needed to treat (NNT) with a ≥80% adherence to medication to prevent a facture of the type specified; n/a, not applicable, indicating that relative risk estimates from Table 2 did not show a protective effect.