Table 2. Half-Lives of Tetrahydropyranyl Derivative 12 at Various pH Levels at 37 °C.

pH	t1/2 (min)
14.0 (1.0 M NaOH)	2.5
13.0 (0.10 M NaOH)	2.7
12.1 (0.0125 M NaOH)	3.5
10.0 (0.05 M glycine/NaOH)	2.9
8.1 (0.10 M phosphate)	3.5
7.4 (0.10 M phosphate)	3.1
4.0 (0.05 M citrate)	3.2