Table 4.
Gene-based tests for SNPs using minP permutation procedure (10,000 replicates).
| GENE | SNP | p-value (gene) | p-value (snp) | Odds Ratio |
|---|---|---|---|---|
| CHRNA2 | rs2280376 | 0.007 | 0.002 | 1.60 (1.19, 2.15) |
| HTR3A | rs10160548 | 0.033 | 0.021 | 1.37 (1.05, 1.81) |
| OPRM1 | rs495491 | 0.060 | 0.006 | 1.47 (1.11, 1.96) |
| CYP2B6 | rs2306606 | 0.082 | 0.018 | 0.69 (0.52, 0.94) |
Note: Odds ratios are allelic odds ratios with 95% confidence intervals.