Scheme 1.
Conditions and reagents: (a) LiHMDS, R2CHO, THF, −78 °C; (b) Et3N, MsCl, DBU, CH2Cl2, 0°C → rt; (c) (7) CAN, CH3CN, 0 °C; or (8) TBAF, THF; (d) (9) Et3N, DMAP, R1COCl; or (10) pyridine, CH2Cl2 then R1COCl, 0 °C; (e) BCl3, CH2Cl2, −78°C.
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