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. Author manuscript; available in PMC: 2009 Sep 11.
Published in final edited form as: J Med Chem. 2008 Aug 16;51(17):5371–5386. doi: 10.1021/jm800380b

Table 3.

Affinity ratios between PKCα and RasGRP3 for compounds 12a-r.

E-isomer Ki ratio PKCα/RasGRP-3 Z-isomer Ki ratio PKCα/RasGRP-3
12a-E 43
12b-E 13 12b-Z 20
12c-E 19 12c-Z 14
12d-E 14 12d-Z 8
12e-E 6 12e-Z 3
12f-E 47
12g-E 32 12g-Z 11
12h-E 10 12h-Z 4
12i-E 27 12i-Z 7
12j-E 16 12j-Z 2
12k-E 8 12k-Z 6
12l-E 64
12m-E 119 12m-Z 16
12n-E 47 12n-Z 5
12o-E 45 12o-Z 20
12p-E 31 12p-Z 17
12q-E 27 12q-Z 5
12r-E 165