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. Author manuscript; available in PMC: 2009 Sep 11.
Published in final edited form as: J Med Chem. 2008 Aug 16;51(17):5371–5386. doi: 10.1021/jm800380b

Table 4.

Affinity ratios between PKCα and RasGRP3 for compound 12m-E versus 12s-E and compound 12r-E versus 12t-E.

Compound SlogP PKCα Ki (nM) RasGRP-3 Ki (nM) Ratio PKCα/RasGRP-3
graphic file with name nihms58122t54.jpg
12m-E 		2.9026 86.3 ± 0.7 0.72 ± 0.1 119
graphic file with name nihms58122t55.jpg
12s-E 		3.7847 4.6 ± 0.5 0.20 ± 0.04 23
graphic file with name nihms58122t56.jpg
12r-E 		4.3585 29.7± 1.1 0.18± 0.03 165
graphic file with name nihms58122t57.jpg
12t-E 		5.2406 14.8± 1.0 0.70± 0.02 21