Table 4.

Univariate and Multivariate HRs* for the Development of Any New Fracture (N = 1369) Among 1964 Rochester, MN, Residents After Recognition of Diabetes Mellitus in 1970–1994

Risk factor†	Univariate [HR (95% CI)]	Age-adjusted [HR (95% CI)]	Multivariate [HR (95% CI)]
Age at recognition (per 10 yr)	1.5 (1.4–1.6)	—	1.3 (1.2–1.4)
Female sex	1.7 (1.5–2.0)	1.6 (1.3–1.9)	1.6 (1.3–1.9)
Prior osteoporotic fracture	2.5 (1.6–3.8)	1.8 (1.2–2.7)	1.6 (1.03–2.4)
Physically active	0.4 (0.3–0.5)	0.5 (0.4–0.7)	0.6 (0.5–0.8)
BMI (per unit increase)	0.97 (0.95–0.98)		0.98 (0.97–0.99)
Secondary osteoporosis	1.5 (1.3–1.8)	1.4 (1.2–1.6)	1.2 (1.1–1.5)
Renal failure	1.8 (1.4–2.5)	1.6 (1.2–2.2)
Falling factors	1.5 (1.2–1.7)
Neuropathy	1.4 (1.2–1.7)	1.4 (1.2–1.7)	1.3 (1.1–1.6)
Neuropathy	1.3 (1.1–1.5)	1.5 (1.3–1.7)	1.3 (1.1–1.5)
Use of biquanides	0.6 (0.5–0.8)	0.7 (0.6–0.95)	0.7 (0.6–0.96)
Use of thiazolidinediones	0.6 (0.4–0.9)
Use of corticosteroids	2.0 (1.6–2.4)	1.9 (1.6–2.3)	1.6 (1.3–2.0)
Use of osteoporosis drugs	3.1 (2.1–4.6)	2.5 (1.7–3.7)	2.0 (1.4–2.9)
Use of estrogens	1.4 (1.1–1.7)	1.5 (1.2–1.8)
Use of progestins		2.2 (1.4–3.5)
Use of SERMS	3.1 (1.6–6.2)	2.6 (1.3–5.3)
Use of diuretics	1.3 (1.1–1.6)
Use of anticoagulants	1.5 (1.3–1.8)	1.3 (1.1–1.5)
Use of thyroid replacement	1.4 (1.2–1.7)	1.4 (1.2–1.7)

* Proportional hazards models where the event is a fracture and the dependent variable is survival time (days) free of fracture.

^† Only risk factors that were significant in the univariate and/or multivariate analysis are included in the table.