Table 5.

Multivariate HRs* for the Development of a New Moderate Trauma Fracture (N = 1061). Osteoporotic Fracture (N = 562), or Hip Fracture (N = 101) Among 1964 Rochester, MN, Residents After Recognition of Diabetes Mellitus in 1970–1994

Risk factor†	[Moderate trauma HR (95% CI)]	Osteoporotic fracture [HR (95% CI)]	Hip fracture [HR (95% CI)]
Age at recognition (per 10 yr)	1.5 (1.4–1.7)	1.6 (1.5–1.8)	2.0 (1.7–2.5)
Female sex	1.8 (1.5–2.1)	1.6 (1.3–2.0)
Prior osteoporotic fracture	1.7 (1.1–2.6)
Physically active	0.6 (0.5–0.9)	0.7 (0.5–0.98)	0.5 (0.3–0.96)
BMI (per unit increase)	0.8 (0.7–0.99)	0.8 (0.6–0.98)	0.95 (0.91-0.99)
BMI (≥30)
Secondary osteoporosis	1.4 (1.1–1.7)	1.4 (1.1–1.8)
Falling factors	1.2 (1.01–1.5)	1.3 (1.1–1.7)	5.2 (2.7–10)
Neuropathy	1.4 (1.1–1.7)
Use of insulin	1.3 (1.1–1.6)	1.3 (1.04–1.7)
Use of biquanides	0.7 (0.5–0.97)
Use of corticosteroids	1.5 (1.2–1.8)	1.6 (1.3–2.0)
Use of osteoporosis drugs	2.0 (1.4–3.0)	2.2 (1.3–3.8)	3.9 (1.5–9.9)
Use of anticoagulants		1.4 (1.1–1.7)

* Proportional hazards models where the event is a fracture and the dependent variable is survival time (days) free of fracture.

^† Only risk factors that were significant in the multivariate analysis are included in the table.