Adolescent fluoxetine treatment did not affect anxiety-related behaviors in the elevated plus-maze test in either BALB/cJ or C57BL/6J mice. Open arm exploration (a), open arm entries (b), and closed arm entries (c) in the elevated plus maze was no different between mice receiving the lower dose of fluoxetine (FLX) relative to water-treated controls, irrespective of strain. Open arm exploration (d), open arm entries (e), and closed arm entries (f) was no different between mice receiving the higher fluoxetine dose compared to water-treated controls, irrespective of strain. BALB/cJ consistently showed greater open arm avoidance than C57BL/6J. **p<0.01 BALB/cJ vs. C57BL/6J. n=10/strain/treatment/dose. Data are means±SEM