Representative plots of the absorbance changes elicited by increasing concentrations of (+)-, (-)- or (±)-PCB 136 with mouse hepatic microsomes (3 experiments for PB and DEX, single experiment for NF and CO). Increasing amounts of PCB were added separately to 1 mL sample cuvettes containing hepatic microsomes, at 4 nmol P450/mL, prepared from NF- (A), PB- (B), DEX- (C), and CO-treated (D) mice. Difference spectra were recorded and ΔA values calculated as described in Experimental Procedures.