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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: J Pharmacol Exp Ther. 2008 Apr 30;326(2):546–554. doi: 10.1124/jpet.108.137414

Figure 8.

Figure 8

Simulated profiles of femur BMD (Panel A), lumbar BMD (Panel B), TNF-α mRNA (Panel C), IL-1β mRNA (Panel D), IL-6 mRNA (Panel E), DRN (Panel F), and paw edema (Panel G) following no drug treatment (solid black lines), chronic 0.0113 mg/kg DEX daily (gray lines), and 0.225 mg/kg DEX daily (black long-short dashed lines) in arthritic rats. Short dashed lines depict BMD responses in healthy rats. DEX dosing begins 504 hours post induction and is repeated every 24 hours for the remainder of the simulation.