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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Clin Exp Pharmacol Physiol. 2008 Apr 21;35(8):957–964. doi: 10.1111/j.1440-1681.2008.04934.x

Table 5.

VEGF Expression for Healing Wounds Treated with TO

Time Interval1 Oxygen Treatment Number healing wounds VEGF Ratio2 p-value3
T2 to T0 Topical Oxygen 9 2.54 0.010
T2 to T1 Topical Oxygen 8 2.81 0.232
T1 to T0 Topical Oxygen 14 4.02 0.070
1

T0= baseline measurement; T1 = midpoint of therapy; T2 = 14 weeks or imminent closure

2

VEGF ratio = log transformed ratio of VEGF/β-actin (Tx): VEGF/β-actin (Ty) where Tx = first T in time interval and Ty = second T in time interval

3

p-value is testing if the healing VEGF ratio is significantly greater than 1.0 and is generated from a one–sample t-test that uses the natural logarithm of the VEGF ratio.