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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Drug Metab Dispos. 2008 May 14;36(8):1594–1605. doi: 10.1124/dmd.108.020552

Figure 4. Effect of duration of preincubation (0, 20, 40, and 60 min with inhibitor and NADPH regeneration system) on the extent of inhibition of CYP3A-mediated triazolam 1′-and 4-hydroxylation by 12.5μM (A) and 50μM (B) curcuminoid extract in human liver microsomes.

Figure 4

Assay details are provided in the text. Column heights correspond to the mean ± standard error of triplicate determinations using HLM from three different individuals.