Table 2. 8-Prenylnaringenin measured in rat plasma, liver, and mammary glands using LC-MS-MS.
| Treatment group |
1Plasma
(N=6) |
1Liver
(N=6) |
1Mammary gland
(N=6) |
|---|---|---|---|
| (ng/mL) | (μg/g tissue) | (μg/g tissue) | |
| Control | <0.5002 | <0.0022 | 0.003 ± 0.0022 |
| Estradiol | <0.5002 | <0.0022 | 0.004 ± 0.0032 |
| 0.4 mg/kg of 8-PN | <0.5002 | 0.10 ± 0.05 | 0.014 ± 0.014 |
| 4.0 mg/kg of 8-PN | <0.5002 | 0.4 ± 0.3 | 0.047 ± 0.046 |
| 40 mg/kg of 8-PN | 3.7 ± 1.63 | 4.4 ± 4.13 | 0.6 ± 0.43 |
1
Values are expressed as mean ± S.D.
2
Below the limit of quantitation
3
The difference from control was determine using one-way ANOVA with Dunnett posthoc test (p< 0.01)