Figure 1.

Alignment of mouse and human b^0,+AT amino acid sequences with hLAT1 and hy⁺LAT1. Amino acids identical to those of mb^0,+AT are shown in boldface type. Putative transmembrane domains (TMDs), the positions of which represent compromises based on the predictions obtained for the different sequences (TMpred server, Swiss Institute for Experimental Cancer Research), are numbered from 1 to 12. The conserved cysteine residue known to be involved in the disulfide bond of LAT1 (Pfeiffer et al., 1998) with h4F2hc is indicated by the letter C.