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Model sensitivity analysis for cytokine effects on paw edema. Panels A–C show simulated time courses of paw swelling for 0, 50, or 100 % inhibition of TNF-α, IL-1β, or IL-6 cytokine mRNA expression. Panels D–F show simulated time courses for 0, 50, or 100 % inhibition of TNF-α and IL-1β, TNF-α and IL-6, or IL-1β and IL-6 cytokine mRNA jointly.
