Table 2.
Pro-inflammatory Cytokine mRNA Disease Progression Parameters
| Parameter (units) | Description | Estimatea |
|---|---|---|
| TNF0(ng/mg_RNA) | TNF-α mRNA baseline | 14.97b |
| kt1 (hr−1) | TNF-α transduction rate constant | 0.08889b |
| kin_TNFα(hr−1) | TNF-α mRNA synthesis rate constant | 186.5 |
| kdis_TNFα(ng/mg_RNA) | TNF-α mRNA disease steady-state | 13.11 |
| IC50_TNFαDRN(nMol) | IC50 for CST effects on TNF-α mRNA via GR | 550.0 |
| γ1 | Hill coefficient of CST effects on TNF-α mRNA | 2.000b |
| IL1β0(ng/mg_RNA) | IL-1β mRNA baseline | 5.730b |
| kt2 (hr−1) | IL-1β mRNA transduction rate constant | 0.0345b |
| kin_IL1β(hr−1) | IL-1β mRNA synthesis rate constant | 24.82 |
| kdis_IL1β(ng/mg_RNA) | IL-1β mRNA disease steady-steady without remission | 70.11 |
| IC50_IL1β/DRN | IC50 for CST effects on IL-1β mRNA via GR | 32.55 |
| IL60(ng/mg_RNA) | IL-6 mRNA baseline | 4.698b |
| kt3 (hr−1) | IL-6 mRNA transduction rate constant | 0.0550b |
| kin_IL6 (hr−1) | IL-6 mRNA synthesis rate constant | 75.21 |
| kdis_IL6 (ng/mg_RNA) | IL-6 mRNA disease steady-state without remission | 3398 |
| IC50_IL6/DRN(nMol) | IC50 for CST effects on IL-6 mRNA via GR | 4.503 |
| γ3 | Hill coefficient of CST effects on IL-6 mRNA | 2.000b |
| IC50_TNF/IL6(ng/mg_RNA) | IC50 for IL-6 inhibition of TNF-α mRNA | 1080 |
| IC50_Rem | Remission Constant for effects on cytokine expression | 15.00b |
a
S-ADAPT Software was unable to generate CV%
b
Parameter value was fixed