Table 5.
Model Parameters for Cancellous and Corticol Bone Mineral Density.
| Parameter (units) | Description | Estimate | CV% |
|---|---|---|---|
| Canc0(g/cm2) | Value of cancellous bone density on study day 0 | 0.08720 | 27.9 |
| kgrowth_Cancellous (hr−1) | Synthesis rate constant for cancellous bone | 0.0002252 | 1370 |
| BMDmax_Cancellous (g/cm2) | Maximum density of cancellous bone | 0.1001 | 16.4 |
| Cort0(g/cm2) | Value of cortical bone density on study day 0 | 0.1586 | 141 |
| kgrowth_Cortical (hr−1) | Synthesis rate constant for cortical bone | 0.003855 | 41.3 |
| BMDmax_Corticol (g/cm2) | Maximum density of corticol bone | 0.2242 | 18.6 |
| ftcort | Fractional effect of ‘Osteoclast’ CMT on cortical bone | 0.09133 | 1460 |
| focort | Fractional effect of ‘Osteoblast’ CMT on cortical bone | 0.7720 | 874 |
| kOC (hr−1) | Synthesis rate constant for ‘OC’ CMT | 0.5985 | 770 |
| ρ1 (ng_TNF−1) | Intrinsic activity of TNF-α mRNA on ‘OC’ CMT | 4.931 × 10−6 | 1690 |
| ρ2 (ng_IL-1β−1) | Intrinsic activity of IL-1β mRNA on ‘OC’ CMT | 5.662 × 10−3 | 1430 |
| ρ3 (ng_IL-6−1) | Intrinsic activity of IL-6 mRNA on ‘OC’ CMT | 6.578 × 10−4 | 1480 |
| kosteoblast (hr−1) | Transit rate constant for glucocorticoid effect | 0.09105 | 43.0 |
| IC50_GC (nM) | Concentration for 50% inhibition of glucocorticoid effect | 984.8 | 137 |