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. Author manuscript; available in PMC: 2009 Sep 2.
Published in final edited form as: Circulation. 2008 Aug 18;118(10):993–1001. doi: 10.1161/CIRCULATIONAHA.108.777334

Table 3.

Associations of Lipids and Apolipoproteins with Cardiovascular Disease, According to Fasting Status and Postmenopausal Hormone Use

Non Hormone Users Nonfasting N=3,531 Fasting N=11,258
Hormone Users Nonfasting N=2,801 Fasting N=8,688
Per 1-SD
 P Value
 Per 1-SD
 P Value
Lipid Concentrations
Total cholesterol
        Nonfasting 1.10 (0.93−1.30) 0.28 1.03 (0.84−1.26) 0.81
        Fasting 1.27 (1.17−1.38) <0.001 1.14 (1.02−1.27) 0.02
Low-density lipoprotein cholesterol
        Nonfasting 1.06 (0.89−1.27) 0.49 0.90 (0.72−1.13) 0.37
        Fasting 1.26 (1.16−1.37) <0.001 1.14 (1.01−1.27)** 0.03
High-density lipoprotein cholesterol
        Nonfasting 0.68 (0.54−0.86) 0.002 0.83 (0.66−1.05) 0.12
        Fasting 0.74 (0.65−0.84) <0.001 0.83 (0.73−0.95) 0.005
Triglycerides
        Nonfasting 1.22 (1.10−1.37) <0.001 1.24 (1.08−1.43) 0.002
        Fasting 1.27 (1.18−1.36) <0.001 1.17 (1.07−1.29) 0.001
Triglycerides*
        Nonfasting 1.12 (0.96−1.30) 0.15 1.26 (1.06−1.49) 0.01
        Fasting 1.07 (0.97−1.18) 0.19 1.06 (0.94−1.19) 0.38
Apolipoprotein Concentrations
Apolipoprotein B100
        Nonfasting 1.25 (1.06−1.47) 0.009 1.14 (0.92−1.41) 0.24
        Fasting 1.40 (1.28−1.53) <0.001 1.31 (1.17−1.46) <0.001
Apolipoprotein A-1
        Nonfasting 0.80 (0.64−1.00) 0.05 0.90 (0.73−1.11) 0.34
        Fasting 0.74 (0.65−0.84) <0.001 0.89 (0.79−1.00) 0.05
Combined Lipid Measures
Non-high-density lipoprotein cholesterol
        Nonfasting 1.19 (1.01−1.41) 0.04 1.09 (0.89−1.34) 0.41
        Fasting 1.35 (1.24−1.47) <0.001 1.21 (1.09−1.35) 0.001
Total/high-density lipoprotein cholesterol ratio
        Nonfasting 1.34 (1.16−1.55) <0.001 1.21 (1.00−1.47) 0.05
        Fasting 1.42 (1.31−1.53) <0.001 1.25 (1.11−1.40) <0.001
Apolipoprotein B100/A-1 ratio
        Nonfasting 1.18 (1.08−1.29) <0.001 1.19 (0.98−1.44) 0.08
        Fasting 1.42 (1.31−1.53)** <0.001 1.32 (1.17−1.48) <0.001

Values shown are hazard ratios (95% confidence intervals) adjusted for age, randomized treatment assignment, smoking status, menopausal status, postmenopausal hormone use, blood pressure, diabetes, and body mass index. P value for linear trend was obtained using the median value for each quintile.

*

Additionally adjusted for total and HDL cholesterol.

**

Likelihood ratio test for interaction with fasting/nonfasting status: LDL cholesterol for hormone users, P for interaction=0.06; apolipoprotein B100/A-1 for non hormone users, P for interaction=0.0002.