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. Author manuscript; available in PMC: 2009 Jul 8.
Published in final edited form as: Biochemistry. 2008 Jun 11;47(27):7137–7146. doi: 10.1021/bi800160s

Figure 1. Structures of various lesions used in this study.

Figure 1

DNA duplexes containing the lesion base OG, the hydantoin products, guanidinohydantoin (Gh) and the two diastereomers of spiroiminodihydantoin (Sp) derived from oxidation of OG, thymine glycol (Tg) and 5-hydroxycytosine (5-OHC) were used as substrates to evaluate the relative processing of these lesions by hNEIL1.