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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Curr Opin Pharmacol. 2008 Aug 12;8(4):440–448. doi: 10.1016/j.coph.2008.07.005

Figure 2.

Figure 2

Androgen synthesis pathway and therapeutic targets. Cholesterol is synthesized from Acetyl-CoA and enzymes in this pathway were found to be upregulated by Holzbeierlein et. al. (red) [10]. Subsequently, the weak androgen androstenedione, testosterone, and the potent DHT are synthesized from cholesterol and enzymes in this pathway were found to be upregulated by Stanbrough et. al. (blue) and Montgomery et. al. (orange) [22,23]. Abiraterone blocks CYP17 which contain both 17α-hydroxylase/C17,20-lyase activities (boxed orange). Dutasteride blocks both SRD5A1 and SRD5A2 (boxed green).