Figure 2.

Alignment of class II lantibiotic sequences. Highly conserved sequences in the leader peptide are highlighted in yellow. Ser/Thr that undergo dehydration are highlighted in blue while Cys that undergo cyclization are labeled in red. The conserved negatively charged residue (Glu/Asp) that has been suggested to be important for antimicrobial activity is labeled in blue font. The arrow denotes the proteolytic cleavage site at which the leader peptide is removed from the mature propeptide.