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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Drug Metab Dispos. 2008 Jul 24;36(10):2086–2092. doi: 10.1124/dmd.108.020842

Figure 1. Hepatobiliary disposition of digoxin in the absence or presence of BSA or BSA-FAF.

Figure 1

Sandwich-cultured rat hepatocytes were incubated with [3H]-digoxin (10 μM) in the absence or presence of 4% (w/v) bovine serum albumin (BSA) or essentially fatty acid-free BSA (BSA-FAF) for 10 min following incubation in standard or Ca2+-free buffer. Filled bars represent accumulation in hepatocytes and bile canaliculi (cell + bile). Open bars represent accumulation in hepatocytes (cell). The biliary excretion index (BEI), unbound intrinsic biliary clearance (intrinsic Cl’biliary), and unbound fraction (fu) were determined as described under Methods. Data are presented as mean ± S.E.M. n = 3 livers in triplicate. Groups with the same letter indicate a statistically significant difference (p < 0.05).