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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Drug Metab Dispos. 2008 Jul 24;36(10):2086–2092. doi: 10.1124/dmd.108.020842

Figure 3. Hepatobiliary disposition of taurocholate in the absence or presence of BSA or BSA-FAF.

Figure 3

Sandwich-cultured rat hepatocytes were incubated with [3H]-taurocholate (1 μM) in the absence or presence of 4% (w/v) BSA or BSA-FAF for 10 min following incubation in standard or Ca2+-free buffer. Filled bars represent accumulation in hepatocytes and bile canaliculi (cell + bile). Open bars represent accumulation in hepatocytes (cell). BEI, intrinsic Cl’biliary, and fu were determined as described under Methods. Data are presented as mean ± S.E.M. n = 3 livers in triplicate. The taurocholate fu data were log-transformed for statistical comparison. Groups with the same letter indicate a statistically significant difference (p < 0.05).