Fig. 1.
Representative saturation binding analyses of 125I-SI-Ang II binding in the human cerebral cortical (rostral pole of the temporal lobe) membranes (obtained from the 9 h post mortem brains listed in Table 1) in the presence of 10 µM PD123319 and losartan in the absence or presence (indicated with “+”) of 0.3 mM PCMB. In “F+” Bmax=1.80±0.16 fmol/mg wet wt., and Kd=1.61±0.36 nM; “M+” Bmax=1.99±0.18 fmol/mg wet wt., and Kd=1.69±0.39 nM; in the absence of PCMB specific 125I-SI-Ang II binding was not significantly different from zero.