TABLE 1.
Summary of the basal, activated and total currents from T1 and T2 alone, and when coexpressed with different SUR subtypes in Xenopus oocytes
| Basal (µA) | Az-activated (µA) | Dzx-activated (µA) | Pin-activated (µA) | Glib-sensitive (µA) | Total (µA) | n | |
|---|---|---|---|---|---|---|---|
| T1 | −0.80 ± 0.05 (27.09 ± 4.41 %) |
−1.09 ± 0.25 (27.99 ± 3.60 %) |
−1.81 ± 0.48 (44.92 ± 4.24 %) |
−2.63 ± 0.62 (67.29 ± 3.24 %) |
−3.70 ± 0.72 | 8 | |
| T1+SUR1 | −4.72 ± 0.43 (16.77 ± 2.38 %) |
−16.37 ± 1.92 (53.68 ± 2.83 %) |
−10.15 ± 2.75 (29.55 ± 3.82 %) |
−28.34 ± 4.58 (89.71 ± 1.25 %) |
−31.24 ± 4.64 | 8 | |
| T1+SUR2A | −1.37 ± 0.27 (4.25 ± 0.62 %) |
−5.36 ± 0.88 (16.94 ± 1.79 %) |
−6.63 ± 1.78 (18.87 ± 2.93 %) |
−18.69 ± 2.67 (59.94 ± 3.09 %) |
−27.37 ± 4.56 (85.24 ± 1.47 %) |
−32.04 ± 5.21 | 8 |
| T1+SUR2B | −1.60 ± 0.20 (8.36 ± 1.24 %) |
−8.00 ± 1.25 (37.31 ± 2.98 %) |
−11.04 ± 1.13 (54.33 ± 2.45 %) |
−14.99 ± 1.50 (74.14 ± 3.45 %) |
−20.63 ± 2.27 | 8 | |
| T1+MRP1 | −0.19 ± 0.17 (11.00 ± 8.75 %) |
−0.81 ± 0.11 (42.86 ± 4.56 %) |
−0.92 ± 0.07 (49.32 ± 3.06 %) |
−1.03 ± 0.14 (54.46 ± 5.77 %) |
−1.87 ± 0.11 | 5 | |
| T2 | −0.87 ± 0.08 (13.04 ± 1.19 %) |
−0.14 ± 0.05 (2.09 ± 0.72 %) |
−0.46 ± 0.05 (6.74 ± 0.55 %) |
−5.21 ± 0.20 (78.13 ± 1.06 %) |
−4.16 ± 0.23 (62.36 ± 2.69 %) |
−6.68 ± 0.24 | 7 |
| T2+SUR1 | −1.56 ± 0.32 (2.77 ± 0.98 %) |
−6.28 ± 1.35 (7.52 ± 1.00 %) |
−11.02 ± 1.59 (15.16 ± 1.96 %) |
−61.28 ± 12.57 (74.55 ± 2.14 %) |
−76.45 ± 14.47 (95.15 ± 0.62 %) |
−80.13 ± 14.87 | 7 |
| T2+SUR2A | −0.53 ± 0.15 (2.71 ± 0.92 %) |
−0.08 ± 0.06 (0.57 ± 0.36 %) |
−0.27 ± 0.05 (1.67 ± 0.42 %) |
−17.48 ± 1.69 (95.05 ± 0.58 %) |
−15.97 ± 1.55 (86.84 ± 2.15 %) |
−18.36 ± 1.73 | 9 |
| T2+SUR2B | −0.95 ± 0.24 (7.28 ± 1.51 %) |
−0.22 ± 0.12 (2.76 ± 1.42 %) |
−0.98 ± 0.11 (8.44 ± 0.51 %) |
−10.10 ± 1.73 (81.52 ± 1.32 %) |
−8.53 ± 1.39 (69.09 ± 2.72 %) |
−12.25 ± 1.96 | 7 |