. Author manuscript; available in PMC: 2009 Aug 1.

Published in final edited form as: Mol Pharmacol. 2008 May 5;74(2):392–402. doi: 10.1124/mol.108.046946

TABLE 2.

Effect of the most potent TNF-α inducers on Ca²⁺ mobilization, chemotaxis, and ROS production in human polymorphonuclear leukocytes (PMN) and murine J774.A1 macrophages (Mϕ)

Compound	Ca²⁺ Mobilization EC₅₀ (µM)		Chemotaxis (%)^a		ROS Production AC₅₀ (µM)
Compound	Human PMN	Murine Mϕ	Human PMN	Murine PMN	Human PMN	Murine Mϕ
1	0.3±0.2	24.1±4.1	67.8±9.4	68.9±7.8	0.2±0.02	25.4±4.0
2	0.6±0.4	2.3±0.15	91.3±1.6	58.0±1.4	0.2±0.04	8.6±2.7
AG-14	0.63±0.39	4.2±0.8	98.0±3.4	174.8±9.2	38.6±3.3	26.9±3.9

Chemotactic responses are expressed as percent of response induced by 50 nM IL-8 or 50 nM KC in human and murine neutrophils, respectively.