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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Microvasc Res. 2008 Jul 29;76(3):145–151. doi: 10.1016/j.mvr.2008.07.003

Fig. 4. Integrin α3β1 is required for TIMP-2 inhibition of FGF-2-stimulated cell proliferation.

Fig. 4

Quiescent hMVECs were pre-treated with or without function-blocking anti-integrin antibodies (except for β1 (LM534), 10-25 μg/ml) for 20 min, followed by Ala+TIMP-2 (50 nM) for 15 min prior to FGF-2 (50 ng/ml) stimulation for 24 h. Results shown are the percentage of maximal inhibition of cell proliferation obtained by Ala+TIMP-2 and FGF-2 treatment. Values represent the mean ± S.D. of triplicate determinations.