Fig. 4.

T-cell independent antitumor effect of IT IC. a Groups of SCID mice were implanted with 3 × 10⁵ B16-KSA cells on day 0. Mice were treated with 15 μg IT huKS-IL2 or PBS (50 μl) on days 7–11. (p = 0.006 for IT IC vs. IT PBS, day 16). b Groups of nude mice (five per group) were implanted with 5 × 10⁷ M21 cells on day 0. Mice were treated with 5 μg IT hu14.18-IL2 or or IT PBS (50 μl) on days 9–13 and 16–20. (p = 0.04 for IT IC vs. IT PBS, days 22–28)