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. Author manuscript; available in PMC: 2009 Jan 3.
Published in final edited form as: Nature. 2008 May 25;454(7200):118–121. doi: 10.1038/nature06995

Figure 3. GluR2-lacking AMPA receptors are detected in accumbens neurons after prolonged withdrawal from self-administration of cocaine.

Figure 3

a, Evoked EPSC recorded after 42–47 days of withdrawal from saline or cocaine self-administration. b, Current–voltage relationships for neurons shown in a. c, Rectification index (EPSC−70 mV/EPSC+40 mV; Supplementary Information) from 13 and 8 neurons recorded from four cocaine-exposed and three saline-exposed rats (t19 = 3.47; asterisk, P < 0.01). Data are means and s.e.m. d, e, Naspm (200 μM, 5–10 min) decreased evoked EPSC amplitude in cocaine-exposed rats (e) (t6 = 4.72; asterisk, P < 0.01, baseline versus Naspm, seven cells per group) but not in saline-exposed rats (d). f, The effect of Naspm illustrated as the evoked EPSC amplitude normalized to baseline (t12 = 3.73; asterisk, P < 0.01). g, Representative traces illustrating the effect of Naspm after 10 min of bath application. h, Location of recordings. Numbers indicate distance rostral to Bregma (B) in mm.