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. Author manuscript; available in PMC: 2008 Oct 29.

Published in final edited form as: Pharm Res. 2008 Jun 27;25(9):2002–2011. doi: 10.1007/s11095-008-9608-1

(A) 3D MIP images (coronal view) of mice receiving 0.05 mmol-Gd/kg PEG-PGA-(Gd-DO3A)-Mce₆ (top panel), PGA-(Gd-DO3A)-Mce₆ (middle panel), and PGA-(Gd-DO3A) (bottom panel) before (a) and at 2min (b), 5 min (c), 15 min (d), 30 min (e), 2 hours (f) and 18 hours (g) post injection. (B) 2D spin-echo axial images of tumor in mice receiving 0.05 mmol-Gd/kg PEG-PGA-(Gd-DO3A)-Mce₆ (top panel), PGA-(Gd-DO3A)-Mce₆ (middle panel), and PGA-(Gd-DO3A) (bottom panel) before (a) and at 2min (b), 30 min (c), 2 hours (d) and 18 hours (e) post injection. Arrow points to kidneys and arrowhead points to tumor.

(A) 3D MIP images (coronal view) of mice receiving 0.05 mmol-Gd/kg PEG-PGA-(Gd-DO3A)-Mce₆ (top panel), PGA-(Gd-DO3A)-Mce₆ (middle panel), and PGA-(Gd-DO3A) (bottom panel) before (a) and at 2min (b), 5 min (c), 15 min (d), 30 min (e), 2 hours (f) and 18 hours (g) post injection. (B) 2D spin-echo axial images of tumor in mice receiving 0.05 mmol-Gd/kg PEG-PGA-(Gd-DO3A)-Mce₆ (top panel), PGA-(Gd-DO3A)-Mce₆ (middle panel), and PGA-(Gd-DO3A) (bottom panel) before (a) and at 2min (b), 30 min (c), 2 hours (d) and 18 hours (e) post injection. Arrow points to kidneys and arrowhead points to tumor.