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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: J Pain. 2008 Jul 17;9(10):962–969. doi: 10.1016/j.jpain.2008.06.001

Figure 3.

Figure 3

Hotplate and tail withdrawal assays in the U50 study. A, Averaging across all groups before and after injection in the hotplate test, the U50 group had longer latencies than controls (U50 vs. sal, ***p<0.0001), but MK did not block the effect of U50 (U50-MK vs. sal, ***p<0.0001). B, Hotplate latencies as a function of time and sex and sex chromosome complement. There was a significant interaction of time and sex chromosome complement -- XX and XY mice had longer latencies than XX mice only at T=90 (*p<0.05). To show this interaction, which did not depend on drug treatment, data from all drug treatment groups, including saline, are combined for each of the FCG groups. C, Averaging across time and sex and sex chromosome complement, U50 with or without MK significantly increased latencies in the tail withdrawal test (U50 vs. sal, and U50-MK vs. sal, both ***p<0.00001).

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