Table 2.
Correlation of regional brain mu-opioid receptor (mOR) binding after one week or 12 weeks of enforced abstinence with time to relapse to cocaine use in 15 cocaine-dependent subjects.
| One week of abstinence
|
12 Weeks of abstinence
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Voxel-based Analysis in SPM | Cluster-based linear regression analysis in SPSS | Voxel-based Analysis in SPM | Cluster-based linear regression analysis in SPSS | |||||||||
| Brain region | MNI x,y,z coordinatea | max-z | cluster kb (p-value)c | r2 | F 1,13 | p-valued | MNI x,y,z coordinatea | max- z | cluster kb (p-value) c | r2 | F 1,13 | p-valued |
| Frontal | (−20,56, −16) | 4.41 | 168 (0.024) | 0.69 | 28.54 | 0.0001 | (−22,54, −14) | 3.58 | 180 (0.018) | 0.69 | 29.19 | 0.0001 |
| Frontal | (−44,14,8) | 3.42 | 65 (0.138) | 0.62 | 21.27 | 0.0004 | ||||||
| Frontal | (42,36, −2) | 4.26 | 74 (0.115) | 0.70 | 30.92 | <0.0001 | (34,44, −20) | 3.55 | 87 (0.085) | 0.57 | 17.09 | 0.001 |
| Temporal | (−46,18, −34) | 3.55 | 171 (0.021) | 0.66 | 25.44 | 0.0002 | ||||||
a
location of peak expressed as x,y,z coordinates in Montreal Neurological Institute (MNI) space.
b
cluster size k represents number of voxels (2 × 2 × 2 mm3) at a height threshold of p = 0.005, uncorrected.
c
p-value for significance of cluster size in voxel-based analysis in SPM.
d
p-value for significance of relationship between mOR binding and time to relapse in linear regression analysis outside SPM.