Table 3.
Correlation of regional brain mu-opioid receptor (mOR) binding after 12 weeks of enforced abstinence with proportion of days with cocaine use during 30 days after relapse in 15 cocaine-dependent subjects
| Voxel-Based Analysis in SPM | Cluster-based multiple regression analysis in SPSS | ||||||
|---|---|---|---|---|---|---|---|
| Side of brain | Brain region | max-z | MNI coordinatea | Cluster kb (p-valuec) | r2 | F 1,13 | p-valued |
| R | Anterior cingulate | 3.44 | (18,50,2) | 85 (0.081) | 0.70 | 30.16 | 0.0001 |
| R | Frontal | 3.22 | (28,42, −22) | 67 (0.117) | 0.52 | 13.85 | 0.002 |
| R | Frontal | 3.57 | (26, 68, −2) | 63 (0.127) | 0.58 | 18.17 | 0.0009 |
| L | Frontal | 3.48 | (−20,52, −12) | 82 (0.086) | 0.61 | 20.08 | 0.0006 |
| L | Frontal | 3.63 | (−44,54,0) | 51 (0.167) | 0.62 | 21.30 | 0.0004 |
a
location of peak expressed as x,y,z coordinates in Montreal Neurological Institute (MNI) space.
b
Cluster size k represents number of voxels (2 × 2 × 2 mm3) at a height threshold of p = 0.005, uncorrected.
c
p-value for significance of cluster size in voxel-based analysis in SPM.
d
p-value for significance of relationship between mOR binding and proportion of days with cocaine use in multiple-regression analysis outside SPM.