. Author manuscript; available in PMC: 2009 Nov 1.

Published in final edited form as: Psychopharmacology (Berl). 2008 Sep 2;200(4):475–486. doi: 10.1007/s00213-008-1225-5

Table 4.

Significant univariate clinical predictors, and comparison with PET regional brain mu-opioid receptor (mOR) binding predictor, of time to lapse and to relapse to cocaine use in 15 cocaine-dependent subjects

Predictor Variable	Time to Lapse^*			Time to Relapse^*
	Beta [SE]	R²	P	Beta [SE]	R²	P
*Univariate Predictors*
ASI Drug Composite Score	134.9 [23.0]	0.71	<0.0001
ASI Legal Composite Score	73.3 [10.7]	0.78	<0.0001
ASI Family/Social Composite Score	138.6 [29.4]	0.63	<0.0001
Lifetime Alcohol Use (yrs)				0.18 [0.06]	0.44	0.007
*Multivariate Predictors*^#
ASI Legal Composite Score	56.2 [8.4]	0.78	0.0001
mOR binding variable^@	31.9 [7.9]	0.13	0.002
Lifetime Alcohol Use (yrs)				0.82 [0.34]	0.07	0.03
mOR binding variable^@				9.61 [1.61]	0.79	< 0.001

analyzed as log (days) because of skewed distributions

based on stepwise multiple regression analysis with entry criterion of F value significance < 0.001

decrease in mOR binding in right inferior frontal cortex between one and 12 weeks of abstinence

PET = positron emission tomography, ASI = Addiction Severity Index