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. Author manuscript; available in PMC: 2008 Oct 29.
Published in final edited form as: J Org Chem. 2008 Jun 6;73(13):4819–4829. doi: 10.1021/jo8002198

Scheme 7.

Scheme 7

Two potential pathways for the cyclization reactions. The concerted reaction is shown in pathway a. If a phosphorane intermediate forms, as in pathway b, the leaving group may or may not initially be in the apical position required for departure as shown. If not, pseudorotation will be required before expulsion and product formation can occur.