Figure 2.

Graphs showing relationship between time of abstinence and the GLX concentration in (A) frontal gray matter and (B) frontal white matter. The dotted black lines and the R and p-values represent the result of a linear regression. The red solid lines show the results of a mono-exponential model with a negative time-constant and a positive offset. This model is more realistic in that it represents a gradual initial rise in the GLX concentration with time towards a “steady-state” level over longer time periods. The equations show the fitted dependence of the GLX concentration (in mM) on time (in months). While the mono-exponential fit yielded a good result for the frontal gray matter GLX (A), the result was less robust for the frontal white matter (see Text).