Table 2.

Effect of Ethanol (C2, 190 mM) and Octanol (C8, 0.057 mM) on Activation and Inactivation of Four Different Sodium Channels (See Figures 4 and 5 for Details)

	Holding −90 mV			Holding V1/2
Activation	Control	C2	C8	Control	C2	C8
	V1/2(mV)
Nav1.2	−32.2 ± 0.4	−29.5 ± 1.0*	−28.9 ± 0.8**	−25.2 ± 0.4	−22.2 ± 0.4**	−22.5 ± 0.4**
Nav1.4	−42.6 ± 0.4	−41.8 ± 0.9	−42.5 ± 0.1	−32.7 ± 1.1	−29.5 ± 3.0	−27.8 ± 2.3
Nav1.6	−33.0 ± 0.7	−30.8 ± 1.1	−30.3 ± 1.6	−26.8 ± 0.5	−24.6 ± 0.9	−23.6 ± 0.7**
Nav1.8	4.2 ± 0.4	6.0 ± 0.8	5.1 ± 0.8	5.0 ± 0.6	7.8 ± 0.5	6.2 ± 1.4
Inactivation	Control	C2	C8
	V1/2 (mV)
Nav1.2	−55.3 ± 0.6	−56.3 ± 0.8	−58.7 ± 0.9**
Nav1.4	−55.7 ± 0.3	−57.9 ± 0.7	−59.3 ± 1.0**
Nav1.6	−59.6 ± 0.6	−60.8 ± 1.0	−63.1 ± 0.5 *
Nav1.8	−53.6 ± 1.4	−55.7 ± 2.5	−55.3 ± 2.6

^*p < 0.05;

^**p < 0.01, compared with control by one-way analysis of variance (mean ± S.E.M.; n = 4–6).