Table 4.
Comparison of Changes in Activation and Inactivation (as the shift in V1/2) Produced by Ethanol (C2), Octanol (C8) And Isoflurane for Results From the Present Study and Previous Publications *
| Activation
|
|||
|---|---|---|---|
| C2 | C8 | Isoflurane | |
| mV | |||
|
| |||
| Nav1.2 | +2.7 (190 mM) | +3.3 (0.057 mM) | +0.3 (0.6 mM) |
| Nav1.8 | +1.8 (190 mM) | +0.9 (0.057 mM) | −0.7 (0.6 mM) |
| DRG (TTX-S) | +0.23 (200 mM) | ||
| DRG (TTX-R) | +0.35 (200 mM) | ||
| Inactivation
|
|||
| C2 | C8 | Isoflurane | |
|
| |||
| mV | |||
|
| |||
| Nav1.2 | −1.0 (190 mM) | −3.4 (0.057 mM) | −8.9 (0.6 mM) |
| Nav1.8 | −2.1 (190 mM) | −1.7 (0.057 mM) | −0.8 (0.6 mM) |
| DRG (TTX-S) | −2.3 (200 mM) | ||
| DRG (TTX-R) | −2.1 (200 mM) | ||
*
Effects of isoflurane on Nav1.2 and Nav1.8 are from Shiraishi and Harris (2004), and the effects of ethanol on TTX-S and TTX-R (DRG) are from Wu and Kendig (1998). Values in parentheses represent the concentrations of alcohols or isoflurane used in the studies. Holding potentials for activation curves were −90 mV in Nav1.2 and Nav1.8, and −80 mV in DRG neurons.