Total CFU (A, C, E) and TnpR-mediated resolution frequencies (B, D, F) at various times post-infection for RIVET strains carrying the indicated fusion genes. Bars represent the mean total CFU/mouse or mean resolution frequencies (n = 4 mice per time point), and each symbol represents the total CFU or the resolution frequency for the B. pertussis population recovered from an individual mouse. An asterisk indicates that the mean resolution frequency differed significantly from the mean at the preceding time point. The dashed lines in panels B, D, and F correspond to the base-line resolution frequencies of the inocula.