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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: J Neurochem. 2008 May 7;106(3):1198–1208. doi: 10.1111/j.1471-4159.2008.05469.x

Figure 1. Neurochemical differences in Gulo−/− mice.

Figure 1

(a) The low (0.033g/l) dose of ascorbic acid was enough for Gulo-low mice to maintain wild-type levels in liver but not in brain. Greater ascorbic acid supplementation (0.33g/l) in the Gulo-sufficient group resulted in higher levels of ascorbic acid than wild-type mice in liver and cerebellum. Gulo-sufficient mice had significantly higher ascorbic acid levels than Gulo-low mice in all areas assayed. (b) F4-Neuroprostanes were elevated in the cortex in both groups of Gulo knockouts despite high ascorbic acid levels in the Gulo-sufficient group. In the cerebellum only Gulo-low mice had elevated neuroprostane levels. Bars represent group mean ± S.E.M. Group differences are depicted as follows: Gulo-low or wild-type control from Gulo-sufficient * P <.05, ** P <.01, *** P <.001.