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A. Hydrogen bonding interactions between SID 26681509 and papain involve catalytic residues Gln19, Cys25, Gly66, Asp158 and Trp177. The distance between the Cys25 sulfur atom and the thiocarbazate carbonyl carbon is 3.287 Å. This is the carbon likely to undergo nucleophilic attack by the sulfur. B. Overlay of papain/CLIK-148 (light green) with computational model of SID 26681509 in papain (tan). There are striking similarities between the binding interactions of the two inhibitors.
